abstract |
The present invention provides the application and drug of a kind of virtual screening compound in preparing kinase inhibitor, which is with the compound of structure shown in Formulas I, Formula II, formula III or formula IV or its pharmaceutically acceptable salt, ester, solvate.It is verified by vitro kinase activity, above compound has excellent inhibitory activity for VEGFR2, FGFR1, HER2, SRC or Braf kinases.It can be used for the diagnosing and treating of kinase mediated disease. |