http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105585557-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-506 |
| filingDate | 2016-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105585557-B |
| titleOfInvention | EGFR inhibitor for targeted therapy of cancer and preparation method and application |
| abstract | The invention discloses a kind of for EGFR inhibitor of targeted therapy of cancer and preparation method and application.The structural formula of the EGFR inhibitor is as shown in formula I, in formula I, R H, OH, NR ', carbon atom number be 1~3 alkyl, carbon atom number be 1~3 alkenyl, aryl or heterocycle, R ' is the alkyl that carbon atom number is 1~3.The EGFR inhibitor can be used for prevention and/or treating cancer, such as application on human skin squamous carcinoma or lung cancer.EGFR inhibitor provided by the invention compares with existing inhibitor (such as AZD9291, afatinib etc.), has novel chemical constitution.EGFR inhibitor of the present invention being capable of the bis- mutation (EGFR of selective depression EGFR T790M/L858R ) cell line, it is and weaker to the cell inhibitory activity of EGFR wild types；Therefore EGFR inhibitor of the present invention, which can be used for treatment, has EGFR T790M/L858R The patients with lung cancer of mutation has smaller side effect (side effect is since Wild type EGFR being inhibited to cause, such as Afatinib). |
| priorityDate | 2016-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 588.