http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105585525-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-18 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-18 |
| filingDate | 2016-02-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-08-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-08-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105585525-B |
| titleOfInvention | A kind of synthetic method of montelukast sodium |
| abstract | The invention discloses a preparation method of montelukast sodium. The method adopts a one-pot method, and 2-(2-(3-(2-(7-chloro-2-quinolyl)vinyl)phenyl )-3-oxopropyl) phenyl) propanol is the starting material, reacts with 1-(mercaptomethyl)-ethyl cyclopropyl acetate, and then hydrolyzes under the action of alkali to obtain montelukast sodium. After purification, montelukast sodium with almost no loss of product and high purity can be obtained. The method has mild reaction conditions, is easy to operate, can obtain a product with high yield and high purity, and is suitable for large-scale industrial production. |
| priorityDate | 2016-02-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 78.