http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105582526-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-18 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-00 |
| filingDate | 2016-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-07-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-07-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105582526-B |
| titleOfInvention | Application of trefoil factor 2 in the preparation of medicines for the treatment and prevention of acute inflammatory diseases of lung/bronchus |
| abstract | The invention belongs to the technical field of biomedicine, and relates to the application of TFF2 protein in the preparation of medicines for treating and preventing acute inflammatory diseases of the lung/bronchus. The invention uses transcriptome chip analysis to screen significant differential genes in lung tissue of mice infected with severe influenza and mild influenza Expression and screening of TFF2 as a protective molecule, through in vitro synthesis of TFF2 protein, it was found that instillation of TFF2 protein can significantly improve the survival rate of influenza-infected mice and reduce the weight loss of mice. Further research found that TFF2 does not affect influenza virus replication, but can reduce the secretion of inflammatory factors, promote the repair of lung mucosa, and reduce lung tissue damage. Because the mechanism of other respiratory pathogens or physicochemical factors causing respiratory tissue damage is similar to influenza virus infection, the protection of TFF2 against influenza virus infection is not specific protection, but a broad-spectrum protection. Therefore, TFF2 plays a role in respiratory pathogens or other factors. played an important protective role in the induced acute inflammatory injury model. |
| priorityDate | 2016-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 80.