http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105566313-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e1fa521ede9fd1bb6eada7947a082746 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-04 |
| filingDate | 2016-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5e6af782c1cddad2476e04512c9c4b1c |
| publicationDate | 2016-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105566313-A |
| titleOfInvention | The synthetic method of ceftaroline axetil intermediate 4-(4'-pyridine)-1,3-thiazole-2-thiol |
| abstract | The invention discloses a method for synthesizing an important antibiotic ceftaroline axetil intermediate 4-(4'-pyridine)-1,3-thiazole-2-thiol, in which ethyl isonicotinate is mixed with Ethyl acetate undergoes Claisen condensation reaction, followed by acidic hydrolysis decarboxylation, bromination reaction with bromine, ring closure with ammonium dithiocarbamate, and finally reflux in glacial acetic acid to obtain the corresponding 4-( 4'-pyridine)-1,3-thiazole-2-thiol. The invention has few synthesis steps and low cost, and the materials used are cheap and easy to obtain, which is beneficial to industrialized production and has little pollution. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109535067-A |
| priorityDate | 2016-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 16.