http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105566261-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-64 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-64 |
| filingDate | 2015-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-07-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-07-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105566261-B |
| titleOfInvention | The preparation method of combretastatin furan type analog |
| abstract | The invention provides the preparation method of combretastatin (combretastatin) furan type analog.The preparation method for examining combretastatin furan type analog A and C of the present invention：Solvent 1, compound P are added in reaction bulb 1 With 3,4,5 TMBs, stirring is lower to add alkali, reacts at room temperature 10 minutes, adds dilute acid for adjusting pH to neutrality, isolates and purifies and obtain combretastatin furan type analog C, C Raney's nickels (Raney Ni) reduce in solvent 2 and obtain compound A.Combretastatin furan type analog B and D preparation method：Solvent 1, compound P are added in reaction bulb 2 With the methoxybenzaldehyde of 3 trimethyl silicane ether 4, stirring is lower to add alkali, reacts at room temperature 10 minutes, adds dilute acid for adjusting pH to neutrality, isolate and purify and obtain combretastatin furan type analog D, D Raney's nickel (Raney Ni) and reduce in solvent 2 to obtain compound B.Have the advantages that yield is high, operation is simple, reaction condition is gentle, agents useful for same is cheap and easy to get, the preparation method of the easy combretastatin furan type analog for realizing industrialized production the invention provides a kind of. |
| priorityDate | 2015-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 58.