http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105566261-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3970ff2929243c84b2f197df598b9c59 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-64 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-64 |
| filingDate | 2015-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_614c3fbeb54f25aa25270db941981e76 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7ad1adc3edf20acaa93e62c5b3fe2288 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bc3c2b2f0268b6dcf92fb3d1731e0304 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3635f009a3b2088527966f92cf29f6ed http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a6dee9eb629a9e4edc71d9093b5a057d |
| publicationDate | 2016-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105566261-A |
| titleOfInvention | Preparation method of combretastatin furan analog |
| abstract | The invention provides a preparation method of combretastatin (combretastatin) furan analogue. The preparation method of cocombretastatin furan type analog A and C of the present invention: add solvent 1 , compound P1 and 3,4,5-trimethoxybenzaldehyde in the reaction bottle, add alkali under stirring, react at room temperature for 10 minutes , adding dilute acid to adjust the pH to neutral, separation and purification to obtain combretastatin furan analog C, C was reduced with Raney nickel (Raney? Ni) in solvent 2 to obtain compound A. The preparation method of combretastatin furan type analogue B and D: add solvent 1, compound P2 and 3 -trimethylsilyl ether group-4-methoxybenzaldehyde in reaction bottle, add alkali under stirring, room temperature reaction 10 Minutes, add dilute acid to adjust the pH to neutral, separate and purify to obtain combretastatin furan analog D, D is reduced with Raney nickel (Raney? Ni) in solvent 2 to obtain compound B. The invention provides a method for preparing combretastatin furan analogs with the advantages of high yield, simple operation, mild reaction conditions, cheap and easy-to-obtain reagents, and easy realization of industrial production. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114644606-A |
| priorityDate | 2015-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
| Predicate | Subject |
|---|---|
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID163966220 http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID465741765 |
Total number of triples: 20.