http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105566149-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C237-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C269-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C221-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-12 |
| filingDate | 2016-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105566149-B |
| titleOfInvention | Chalcone cationic antimicrobial peptide simulant with antimicrobial activity and preparation method thereof |
| abstract | The invention belongs to the field of medicinal chemistry, and discloses a chalcone cationic antimicrobial peptide simulant with antimicrobial activity and a preparation method thereof. A target product is obtained simply and quickly through four steps of reaction, and the main structure is shown as formula I. An in vitro antimicrobial activity test proves that most of the series of compounds show good antibacterial effects on staphylococcus aureus and escherichia coli, and part of compounds also show excellent antimicrobial activity on superbacteria including methicillin-resistant staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE) and carbapenemases enterobacteriaceae (CRE). An in vitro erythrocyte toxicity test also shows that the series of compounds have less erythrocyte toxicity, and therefore, the series of compounds are expected to be used as a novel candidate antimicrobial drug. The formula I is shown in the description. |
| priorityDate | 2016-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 133.