http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105561331-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1e74277852f1aae0a3ff13f59a65456d |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5123 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5146 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-337 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5192 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-337 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-54 |
| filingDate | 2016-01-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_de6b239aeb20496da1fb7549234f64ff http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3749c0971d5f82991b3dbab41f8616f1 |
| publicationDate | 2016-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105561331-A |
| titleOfInvention | Saturated fatty acid modified antitumor drug conjugates, self-assembled nanosystems and preparation methods thereof |
| abstract | The present invention relates to an anti-tumor drug conjugate based on saturated fatty acid modification, as well as a self-assembled nano system and preparation method of the conjugate: ① The conjugate obtained by structural modification of anti-tumor drugs using different saturated fatty acids can be dissolved in water Self-assembled to form spherical nanoparticles with uniform particle size and good stability; ②After optionally adding amphiphilic polymer materials such as DSPE-PEG during the preparation process, the particle size of self-assembled nanoparticles can be reduced and its stability can be enhanced sex. The method of modifying antitumor drugs with saturated fatty acids to construct self-assembled nanosystems provided by the present invention can endow antitumor drugs that are difficult to self-assemble into nanoparticles with self-assembly ability, and the synthesis only needs one-step reaction, which is simple and easy; Compared with the dependent nanosystem and the amphiphilic prodrug micelle system, the self-assembly system has higher drug loading and better stability, the preparation method is simpler, and it is easy for industrial production. Provided new ideas. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106074376-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111000823-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108888773-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106883267-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112121173-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108888773-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112999356-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021121082-A1 |
| priorityDate | 2016-01-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 32.