http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105560178-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-337 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4745 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1075 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0002 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-107 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4745 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-337 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-64 |
| filingDate | 2015-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-02-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-02-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105560178-B |
| titleOfInvention | A reduction-sensitive polypeptide prodrug nanomicelle and its preparation and application |
| abstract | The invention discloses a reduction-sensitive polypeptide prodrug nanomicelle and its preparation and application. The nanomicelle uses a hydrophobic drug as a core and a cell-penetrating peptide as a shell, and the core and the shell are sensitive to reduction through reduction. The present invention designs a relatively simple and universal method for combining two modular molecules with different properties, that is, a hydrophobic drug is connected to an alkynyl group through a reduction-sensitive disulfide bond, and then A functional peptide compound with azide at the end is synthesized, and finally a reduction-sensitive peptide prodrug nanomicelle is prepared through the Click reaction. Taking the present invention as an example, under mild conditions, prodrug nanomicelles with various functions are prepared by Click reaction, and from the release of prodrugs, the prodrugs show good environmental conditions under different in vitro conditions. Responsiveness. |
| priorityDate | 2015-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 109.