http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105541710-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-18 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-18 |
| filingDate | 2016-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-06-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-06-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105541710-B |
| titleOfInvention | A kind of synthetic method of montelukast |
| abstract | The invention discloses a kind of synthetic methods of montelukast.It is to add in 1 (mercapto methyl) cyclopropaneacetic acid and alkali in organic solvent, and two anion aqueous slkalis are stirred to react to obtain at 10 30 DEG C；Quinoline diol compound and triethylamine are dissolved in organic solvent and obtain quinoline diol solution；Paratoluensulfonyl chloride is dissolved in organic solvent and obtains tolysulfonyl solutions of chlorine；Then quinoline diol solution and tolysulfonyl solutions of chlorine are passed through in microreactor by coutroi velocity respectively, hybrid reaction at 10 30 DEG C, obtain p-methyl benzenesulfonic acid ester compounds solution；Then it with 1 (mercapto methyl) cyclopropaneacetic acid, the two anion aqueous slkali hybrid reaction at 10 30 DEG C being passed through, obtains montelukast feed liquid and goes out microreactor, it is post-treated to obtain montelukast solid.The present invention is easy to operate, and each step byproduct of reaction is few, and high income, products obtained therefrom purity is fabulous, and each step reactor product is easily isolated purification, is suitble to industrialized production. |
| priorityDate | 2016-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 69.