http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105541661-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_826e165ba3dedc056ad5b57c2847fbb4 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C253-30 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C253-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C255-19 |
| filingDate | 2015-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1d9867867911ce6cf50bb67b1ea128ef |
| publicationDate | 2016-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105541661-A |
| titleOfInvention | Aminopterin sodium drug intermediate cyanoacetamide synthesis method |
| abstract | The invention relates to an aminopterin sodium drug intermediate cyanoacetamide synthesis method. The method comprises the following steps: (i) 500ml of a N-(3-hydroxyphenyl)acetamide solution is added into a reaction container mounted with a stirrer; the stirring speed is controlled at 100-160rpm, and 3.6mol of ethyl cyanoacetate is slowly added in batches; the temperature of the solution is increased to 40-45 DEG C; the stirring speed is maintained for 90-120min; the solution temperature is reduced to 5-8 DEG C, and solid is precipitated; suction filtration is carried out; an obtained solid is washed 5-7 times with a trifluoroacetic acid solution with the method described in the step (i); drying is carried out in a nitrogen atmosphere, such that light yellow solid is obtained; recrystallization is carried out with 500ml of a cyclohexane solution, such that white crystal cyanoacetamide is obtained. The mass percentage of the N-(3-hydroxyphenyl)acetamide solution in the step (i) is 65-75%. |
| priorityDate | 2015-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 28.