http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105541593-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C253-30 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C57-58 |
| filingDate | 2016-02-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105541593-B |
| titleOfInvention | A kind of synthetic method of pharmaceutical intermediate |
| abstract | The invention discloses a kind of synthetic method of pharmaceutical intermediate, it is by cyano-acetate and 3,5 bis trifluoromethyl halogeno-benzenes are dissolved in solvent the generation decarboxylation cyanomethylation reaction in the presence of palladium catalyst and organophosphor ligand and obtain 2 (3,5 bis trifluoromethyl phenyls) acetonitrile, again 2 (3 are obtained with methylating reagent reaction, 5 bis trifluoromethyl phenyls) 2 methyl propionitrile are that carboxyl obtains target product finally by alkali conversion cyano group.The method for the synthetic intermediate that the present invention is provided is simple to operate, and raw material is cheap and easily-available, and synthesis is easy, will not occur side reaction, with higher yield. |
| priorityDate | 2016-02-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 121.