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filingDate 2015-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2019-02-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2019-02-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-105524110-B
titleOfInvention A kind of synthetic method of the haloalkyl alcohol ester of alkene
abstract The invention belongs to organic synthesis fields, more particularly to a kind of synthetic method of the halogenated alkoxy product of alkene, the synthetic method of the haloalkyl alcohol ester of specifically a kind of alkene, with halogenating agent, organic acid, cyclic ethers and four groups of alkene are divided into raw material, the chemical reaction process of four component of asymmetry catalysis, the ring-opening reaction principle of the nucleophilic conjugate addition and cyclic ethers that are mediated using halogen, high productivity is by various structures and inactive alkene addition, synthesizing halogen oxyalkyl ester R 1 For phosphate radical or sulfonate radical.The present invention have the characteristics that it is easy to operate, efficient, safe, at low cost, can amplify.Products therefrom has anti-chronic myelocytic leukemia, adenocarcinoma of lung, cancer of pancreas, breast cancer, the activity of the cancer of the brain or prostate gland cancer cell.
priorityDate 2014-10-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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