http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105524062-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-14 |
| filingDate | 2015-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105524062-B |
| titleOfInvention | The synthetic method of Tadalafei |
| abstract | The invention discloses the synthetic method in terms of a kind of Tadalafei.The present invention is with 3,4 4-dihydroxy benzaldehydes, D tryptophan methyl ester hydrochlorides for initiation material, and through being condensed cyclization, chloroacetylation, aminolysis cyclization, methyl ring-closure reaction are final obtains product.The present invention with 3,4 4-dihydroxy benzaldehydes is raw material, is condensed ring-closure reaction and makees solvent with nitrile, lower alcohol, nitroparaffins, makees solvent in chlorine acetylation with ethyl acetate or dichloromethane, aminolysis ring-closure reaction has used cheap lower alcohol to make solvent.Compared with other routes, the route have isolate and purify easy, reaction condition is simple, each step high income (often walking yield ＞ 80%), process stabilizing, the shorter production cycle the characteristics of；And avoid using easy drugs piperonal processed, it is not required to, using purge processes such as column chromatographies, be suitable for industrialized production. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110698396-A |
| priorityDate | 2015-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 79.