http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105523957-B
Outgoing Links
Predicate | Object |
---|---|
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-12 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-02 |
filingDate | 2016-01-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2017-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate | 2017-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | CN-105523957-B |
titleOfInvention | The method that one kettle way prepares scheme for lacosamide |
abstract | The invention discloses the method that one kettle way prepares scheme for lacosamide.It is that, using dichloromethane as solvent, D serines and acetylation reagent are reacted, and adjusts pH to 12~13 with organic base after completion of the reaction;Then 5~0 DEG C of temperature is controlled, Methyl triflate is added and is reacted;30~25 DEG C are cooled to, dehydrating agent is added and benzylamine is reacted, the siccative liquid that is concentrated under reduced pressure after completion of the reaction obtains scheme for lacosamide crude product, then is recrystallized to give scheme for lacosamide sterling.The preparation method is simple to operation, and the scheme for lacosamide purity prepared reaches more than 99.90%, and chiral purity reaches 99.90%. |
priorityDate | 2016-01-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 58.