| abstract |
The present invention relates to an mRNA sequence comprising a coding region encoding at least one antigenic peptide or protein of rabies virus or a fragment, variant or derivative thereof. In addition, the present invention relates to a composition comprising a plurality of mRNA sequences comprising a coding region encoding at least one antigenic peptide or protein of rabies virus or fragments, variants or derivatives thereof. In addition, the present invention also discloses the application of the mRNA sequence or the composition comprising multiple mRNA sequences in the preparation of a pharmaceutical composition, especially a vaccine, for example, the pharmaceutical composition, especially a vaccine, is used to prevent or treat rabies virus Infect. The invention also describes a method for treating or preventing rabies using said mRNA sequence. |