| abstract |
The invention discloses a kind of photo-crosslinking biomim betatic and its preparations and application.The monomer of the photo-crosslinking biomim betatic is：Glycidyl methacrylate di(2-ethylhexyl)phosphate choline chitosan hydrochloride.The preparation method includes that the synthesis of di(2-ethylhexyl)phosphate choline chitosan hydrochloride, the synthesis of glycidyl methacrylate di(2-ethylhexyl)phosphate choline chitosan hydrochloride and addition photoinitiator prepare glycidyl methacrylate di(2-ethylhexyl)phosphate choline chitosan hydrochloride three steps of hydrogel.Photo-crosslinking biomim betatic condition of molding of the present invention is quickly, mildly, the di(2-ethylhexyl)phosphate choline group for the double positive charge structures of local branch having, which can be taken into account, to be improved hydrophily, cytotoxicity, antibiotic property and inhibits protein adsorption, obtained biomim betatic has significant broad-spectrum antimicrobial effect under the conditions of physiological environment, it is nontoxic to normal cell, and protein adsorption is can inhibit, there is important application value in bio-medical fields such as medical treatment, health cares. |