http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105504019-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-60 |
| filingDate | 2016-01-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-06-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-06-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105504019-B |
| titleOfInvention | A kind of conjugated biological molecules of antiendotoxin and its preparation and application |
| abstract | The present invention relates to a kind of conjugated biological molecules of antiendotoxin, the conjugated biological molecules are compound shown in general formula Y-CLP-19-amPEG, wherein CLP-19 is horseshoe crab anti-endotoxin factor analogue peptide molecule；Y is selected from one of hydrogen, acyl group, the alkyl of C1-C18, aryl benzyl and allyl；The molecular weight of amPEG is 500,1000,2000,4000,6000,12000 or 20000.With the present invention CLP-19 more unmodified CLP-19 obtained modified through PEG, its direct antibacterial activity is more excellent or suitable, but the former has been obviously improved the affinity with LPS, LPS characteristic is neutralized with better, there is significant progress compared with CLP-19, be expected to be developed into novel treatment of sepsis drug candidate. |
| priorityDate | 2016-01-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 142.