http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105504015-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2016-02-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105504015-B |
| titleOfInvention | A kind of restricted antitumor CTL epitope peptide of MHC-I classes |
| abstract | A kind of restricted antitumor CTL epitope peptide of MHC I classes can be combined with the binding site of people's MHC I class molecules, can activate the epitope peptide of the cytotoxic T lymphocyte of specificity, 2 epitope peptides are with following amino acid sequences：E1, Tyr Ile Met Phe Val Asp Pro Ser Leu；E2, Tyr Leu Val Ala Leu Ser Tyr Thr Leu；The epitope peptide combined with people's MHC I class molecules, for sequestered polypeptide, pattern of fusion polypeptide and mosaic type polypeptide with the amino acid sequence；And the various forms of condensates that one of 2 kinds of polypeptides described above are monomer.The method that the invention is combined using computer modeling technique with experiment, improve the accuracy of epitope peptide screening, peptide material is only the small peptide of 9 peptides, it is readily synthesized in vitro, it can induce and generate notable anti tumor immune response, it is worth, is applied in immunotherapy of tumors technical field with very big commercial industriesization. |
| priorityDate | 2016-02-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 31.