http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105503799-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cbd6afe8bf92cebfc1a738927809ab36 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-90 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-90 |
| filingDate | 2015-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8c7ed8b6fc7001101bff015f880b7b92 |
| publicationDate | 2016-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105503799-A |
| titleOfInvention | Synthesis method of talosalate drug intermediate 2-acetoxybenzoic acid-3-hydroxyphthalide ester |
| abstract | A synthesis method of talosalate drug intermediate 2-acetoxybenzoic acid-3-hydroxyphthalide ester comprises steps as follows: 0.24 mol of acetylsalicylic acid (2), 0.24-0.27 mol of 3-aminophthalide (3), 30-40 ml of isopropyl alcohol and 230-260 ml of cyclohexane are added to a reaction container provided with a stirrer and a reflux condenser, the stirring speed is controlled within 130-160 rpm, reflux is performed for 4-6 h, cyclohexane is evaporated out under the normal pressure, solids are evaporated out through reduced pressure distillation, washed with a salt solution, subjected to suction filtration and recrystallized with ethyl acetate, and white 2-acetoxybenzoic acid-3-hydroxyphthalide ester solids (1) are obtained, wherein the mass fraction of isopropyl alcohol in the step is 65%-70%, and the mass fraction of cyclohexane in the step is 45%-50%. |
| priorityDate | 2015-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 45.