http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105503769-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_55d2d8989f1d88678e523954a877413e |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-13 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-28 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-28 |
| filingDate | 2015-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e6d7cc0afcf466d528626c61da3bc04b |
| publicationDate | 2016-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105503769-A |
| titleOfInvention | Synthesis method of nizatidine drug intermediate 2-dimethylamino methyl-4-chloromethyl thiazole |
| abstract | A synthesis method of a nizatidine drug intermediate 2-dimethylamino methyl-4-chloromethyl thiazole includes the following steps that 0.063 mol of 2-dimethylamino methyl-4-chloromethyl-4-aminothiazoline, 310 ml of cyclohexane, 0.92 mol of stannous chloride and 0.16-0.19 mol of an ortho-nitrotoluene solution are added into a reaction vessel provided with a stirrer and a thermometer, the stirring speed is controlled to be 150-190 rpm, the solution temperature is controlled to be 10-15 DEG C, reaction is performed for 20-25 hours, then the temperature is raised to 60-65 DEG C, the reaction continues for 4-5 hours, the solution temperature is reduced to 20-25 DEG C, solid precipitation, filtration, washing with a saline solution, washing with acetonitrile and dehydration with a dehydrating agent are performed, and recrystallization is performed in triethylamine to obtain the crystal 2-dimethylamino methyl-4-chloromethyl thiazole. |
| priorityDate | 2015-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 55.