http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105503603-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_55d2d8989f1d88678e523954a877413e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C67-313 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-716 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-313 |
| filingDate | 2015-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e6d7cc0afcf466d528626c61da3bc04b |
| publicationDate | 2016-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105503603-A |
| titleOfInvention | Method for synthesizing atropine drug intermediate acetonedicarboxylic acid |
| abstract | A method for synthesizing an atropine drug intermediate acetonedicarboxylic acid includes the following steps that 2.8 mol of hypochlorous phenyl ester solution and 600 ml of sodium chloride solution are added into a reaction container provided with a stirrer, a thermometer and a dropping funnel, the solution temperature is reduced to 3-6 DEG C, stirring speed is controlled to be 110-160 rpm, 3.2-3.6 mol of 3-amino-3-amide-glutaric acid, 1.6 mol of alumina and 300 ml of dimethylbenzene are slowly added in batches, addition time is controlled to be 90-120 min, the solution temperature is slowly raised to 50-55 DEG C, reaction is conducted for 100-150 min, the solution temperature is reduced to 2-5 DEG C, standing is conducted for 3-5 h, 1200 ml of potassium bromide solution is added in the stirring state, white solid is separated out, subjected to suction filtration, washed with a saline solution and cyclohexanone, dehydrated with a dehydration agent and recrystallized in N-methylformamide, and crystal of acetonedicarboxylic acid is obtained. |
| priorityDate | 2015-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 47.