http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105503491-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_55d2d8989f1d88678e523954a877413e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C1-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C11-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C1-00 |
| filingDate | 2015-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e6d7cc0afcf466d528626c61da3bc04b |
| publicationDate | 2016-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105503491-A |
| titleOfInvention | Synthesis method of terbinafine medical intermediate tert-butyl acetylene |
| abstract | A synthesis method of terbinafine medical intermediate tert-butyl acetylene includes the following steps of adding 310 ml of potassium bisulfite solution and 300 ml of potassium bisulfite to a reaction vessel provided with a stirrer, a thermometer, a dropping funnel and a condenser, raising the temperature of the solution to 90-95 DEG C, controlling the stirring speed at 150-170 rpm, dropwise adding 0.73 mol of 1,1-diamido-3,3-dimethylbutane, controlling the dropwise adding time at 3-5 hours, adding 0.81-0.84 mol of hypochloric acid phenyl ester, conducting reaction for 90-120 min, raising the temperature of the solution to 110-115 DEG C, continuing to conduct reaction for 3-5 hours, lowering the temperature of the solution to 10-15 DEG C, separating out solid, conducting filtering, saline solution washing, acetonitrile washing and pressure reduction distillation, collecting fraction of 100-108 DEG C, and conducting recrystallization in cyclohexane to obtain crystal tert-butyl acetylene. |
| priorityDate | 2015-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 98.