http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105497045-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-585 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P13-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P15-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-585 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P5-28 |
| filingDate | 2015-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105497045-B |
| titleOfInvention | Application of the triptophenolide as androgen receptor antagonists |
| abstract | The present invention relates to Chinese medical extract fields, specifically disclose tripterygium root extract triptophenolide (No. CAS：74285 86 2) in the application of application and triptophenolide in preparing treatment androgen disorders and male contraception drug in terms of as androgen receptor antagonists.The present invention is by building reliable androgenic activity screening technique, test inhibiting effect of the multiclass Chinese medical extract to estrogen receptor activity, finally discovery tripterygium wilfordii is a kind of novel androgen receptor antagonists with root extract monomer triptophenolide, can inhibit wild type and the activity of mutability androgen receptor.Further, the present invention tests the activity of the anti-prostate cancer of triptophenolide, it is found that triptophenolide has preferable activity for the prostate gland cancer cell such as LNCaP and 22RV1 of the AR positives. |
| priorityDate | 2015-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 114.