http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105483140-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2760-14134 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2760-14122 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-10062 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-10343 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-5254 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-5256 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-10041 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-861 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-005 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-861 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N7-01 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-12 |
| filingDate | 2016-01-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105483140-B |
| titleOfInvention | It is a kind of using people's replication defective adenoviral as the Ebola virus disease vaccine of carrier |
| abstract | The invention discloses a kind of nucleotide sequence of Ebola virus GP protein codon optimization, the people's replication defective recombined adhenovirus that can express the nucleotide sequence and the application in preparation prevention Ebola virus disease vaccine are also disclosed.The nucleotide sequence is using the 5 type adenovirus of replication deficient human of E1, E3 joint missing as carrier; to integrate the HEK293 cell of adenovirus E 1 gene as package cell line, the protective antigen gene of carrying is Makona plants of envelope glycoprotein genes of Zaire type Ebola virus after codon optimization.After codon optimization, the expression in transfection cell obviously increases envelope glycoprotein gene.After animal is immunized as Ebola virus disease vaccine as carrier using adenovirus in the nucleotide, body can be induced to generate strong cell and humoral immune reaction in a short time.The vaccine preparation method is simple, can be mass produced in a short time, for coping with burst Ebola's epidemic situation and biological terrorist. |
| priorityDate | 2016-01-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 93.