| abstract |
The invention relates to a polyglutamic acid with a star structure, an injectable hydrogel and a preparation method thereof. Firstly, polyaminated β-cyclodextrin was directional synthesized, multiple polymerization initiation sites were introduced, and then the ring-opening polymerization of L-glutamic acid-N-carboxylic acid anhydride was initiated, and then it was modified to serve as a hydrogel. first component. At the same time, the modified polysaccharide polymer is used as the second component, and the two components are mixed in a certain ratio, and the star-shaped polyglutamic acid hydrogel is obtained by chemical crosslinking through Schiff base reaction, and the gelation time is 7-300s. The hydrogel is characterized by good appearance and mechanical properties, as well as biocompatibility and biodegradability. In addition, β-cyclodextrin, as the core of star-shaped polyglutamic acid, provides additional stable cross-linking. The joint site is beneficial to improve the mechanical strength of the hydrogel, and improves the loading and controlled release performance of hydrophobic drugs. The hydrogel has broad application prospects in the fields of drug controlled release, tissue engineering and regenerative medicine. |