| abstract |
The present invention relates to the technical field of organic chemistry, specifically the asymmetric hydrogenation reaction of α-keto acid compounds. The scheme is as follows: Wherein R 1 is phenyl, substituted phenyl, naphthyl, substituted naphthyl, C 1 -C 6 alkyl or aralkyl; said substituent is C 1 -C 6 alkyl, C 1 -C 6 alkoxy Base, halogen; the number of said substituents is 1-3. Wherein M is a chiral spirocyclic pyridine aminophosphine ligand iridium complex with the following structure: Wherein R is hydrogen, 3-methyl, 4- tBu or 6-methyl. |