abstract |
The present invention discloses a compound of formula I, wherein R 1 , R 2 , R 3 , R 4 , L and X are as defined herein. The present invention relates to a compound, a process for its preparation, a pharmaceutical composition comprising the compound, and its use in the prevention and/or treatment of inflammatory disorders, type 2 diabetes, neurological and/or neurodegenerative diseases, autoimmune diseases, proliferative Disease (especially metastatic disease and/or cancer), disease associated with abnormal angiogenesis, cartilage degradation and/or disruption of cartilage homeostasis, especially for the prevention and/or treatment of cancer. The present invention also discloses a method of treatment using the compound, by administering the compound of the present invention for the prevention and/or treatment of said diseases. |