| abstract |
The present invention relates to compounds of the general formula ( I ), wherein R is phenyl or pyridyl, said phenyl or pyridyl is optionally selected from one, two or three lower alkyls substituted by halogen, halogen, Substituents of lower alkoxy, halogen substituted lower alkoxy, cyano or S(O) 2 -lower alkyl, or morpholinyl, dihydropyranyl or piperidinyl, wherein piperidinyl Optionally substituted with halogen, or C(O)O-lower alkyl; R 2 is hydrogen; R 3 is hydrogen, lower alkyl substituted with halogen, -(CH 2 ) n -S(O) 2 -lower Alkyl, -(CH 2 ) n -cycloalkyl or -(CH 2 ) n -lower alkoxy; R 4 is hydrogen or lower alkyl; n is 0, 1 or 2; Salts, racemic mixtures or their corresponding enantiomers and/or optical isomers. The compounds are useful in the treatment of schizophrenia, obsessive-compulsive personality disorder, major depressive disorder, bipolar disorder, anxiety disorders, normal aging, epilepsy, retinal degeneration, traumatic brain injury, spinal cord injury, post-traumatic stress Panic Disorder, Parkinson's Disease, Dementia, Alzheimer's Disease, Cognitive Impairment, Chemotherapy-Induced Cognitive Impairment ("post-chemo brain"), Down's Syndrome, Autism Spectrum Disorder, Hearing Loss , tinnitus, spinocerebellar ataxia, amyotrophic lateral sclerosis, multiple sclerosis, Huntington's disease, stroke and symptoms caused by radiation therapy, chronic stress, optic neuropathy or macular degeneration or alcohol, opiates, methamphetamine, Neuroactive drug abuse-induced disorders of phencyclidine and cocaine. |