http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105461776-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J7-00 |
| filingDate | 2015-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105461776-B |
| titleOfInvention | A kind of synthetic method of progesterone |
| abstract | The invention belongs to the field of organic chemistry, and provides a synthetic method of progesterone, comprising the steps of: 1) 3β-ether-3,5-androstadiene-17-one is slowly added to a solvent with a strong base, and 2- Ethyl chloropropionate undergoes addition and cyclization reaction to obtain 3β-ether-3,5-androstadiene-17,20-epoxy-20-methyl-20-carboxylate ethyl ester; 2) in nitrogen Or under the protection of an inert gas, in a solvent containing lithium chloride, 3β-ether-3,5-androstadiene-17,20-epoxy-20-methyl-20-ethyl carboxylate is decarboxylated at high temperature, The hydrolysis reaction gives progesterone. The method proposed by the invention fundamentally changes the synthetic route, adopts cheap starting materials, reduces reaction steps, is simpler, economical and environmentally friendly, and has a synthetic molar yield of over 90%, which is beneficial to industrial implementation and has high economic benefits. |
| priorityDate | 2015-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 17.