http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105461690-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7c2dc0b28808fb459d93daf1b3bdd2df |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 |
| filingDate | 2015-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3e8b82bb2f0963389b3a017a1cf7831c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_666ee0ce850506dabdd958eecc2ee691 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_01ac9879a146fe8c61fe2907dbb480f4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5c7101c21cc777d64f1de2ba072d9a0a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3beafcda9cd29eb94b4ab370f847ca92 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d5e39f48b913ef4a99532964bc1b1b40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c2a8df6cd534461859ac43e8cf504b9d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9691ada2210ea3d113f10b466b0bf6ab |
| publicationDate | 2016-04-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105461690-A |
| titleOfInvention | Preparation method of high-purity tert-butyl ((5-(2-fluorophenyl)-1-(pyridine-3-yl sulfonyl)-1H-pyrrole-3-yl)methyl)(methyl)carbamate |
| abstract | The invention discloses a preparation method of high-purity tert-butyl ((5-(2-fluorophenyl)-1-(pyridine-3-yl sulfonyl)-1H-pyrrole-3-yl)methyl)(methyl)carbamate, which comprises the following steps: dissolving tert-butyl ((5-(2-fluorophenyl)-1H-pyrrole-3-yl)-N-methyl)methyl carbamate in an organic solvent, adding sodium hydride, heating for reacting, dropwise adding 3-pyridine sulfonyl chloride at low temperature, reacting under stirring for 1-3h, and filtering to obtain a solution of a tert-butyl ((5-(2-fluorophenyl)-1-(pyridine-3-yl sulfonyl)-1H-pyrrole-3-yl)methyl)(methyl)carbamate crude product; adding purified water to the solution, adjusting the pH to weak acidity, cooling, stirring, separating out crystals, carrying out suction filtration, drying a filter cake, pulping with an isopropyl ether and n-heptane mixed solution, carrying out suction filtration and drying to obtain a high-purity product. The process is simple, safe and reliable; the prepared vonoprazan fumarate intermediate tert-butyl ((5-(2-fluorophenyl)-1-(pyridine-3-yl sulfonyl)-1H-pyrrole-3-yl)methyl)(methyl)carbamate has high yield and purity, and is suitable for industrialized scaled production. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106397404-A |
| priorityDate | 2015-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 66.