http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105461653-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d16e06f7d45b63a00859be219a5c44ee |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D275-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D275-06 |
| filingDate | 2015-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eb5400ab67802825cbdc703c6d3e109f |
| publicationDate | 2016-04-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105461653-A |
| titleOfInvention | Synthetic method of piroxicam drug intermediate 3-oxo-1,2-benzisothiazole-1,1-dioxo-2-ethyl acetate |
| abstract | A synthetic method of a piroxicam drug intermediate 3-oxo-1,2-benzisothiazole-1,1-dioxo-2-ethyl acetate comprises the following steps: adding 2.16mol of saccharin amine and 2.1-2.3L of nitromethane into a reaction container provided with a stirrer, a reflux condenser, a dropping funnel and a thermometer, controlling a stirring speed to be 160-190rpm, rising the temperature of a solution to 110-115 DEG C, slowly adding 2.3-2.5mol of ethyl acetate, after adding continuously stirring for 11-13h, distilling off most of the nitromethane, pouring a reactant into a potassium chloride solution, performing suction filtration to obtain a white solid, recrystallizing by using 900ml of propionitrile, reducing the temperature of a solution to 3-5 DEG C, standing for 30-36h, performing suction filtration, washing by using methylbenzene, and dehydrating by a dehydrating agent, thus obtaining the 3-oxo-1,2-benzisothiazole-1,1-dioxo-2-ethyl acetate, wherein the mass fraction of the potassium chloride solution is 15-20 percent, and the mass fraction of the propionitrile is 80-85 percent. |
| priorityDate | 2015-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 29.