http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105461566-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_80fdaa0d94f29478467816f48d47639e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C201-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C201-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C245-20 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C245-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C205-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C201-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C201-12 |
| filingDate | 2015-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0be20f0f2cd2cfe19a93a631f8c6ee8b |
| publicationDate | 2016-04-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105461566-A |
| titleOfInvention | Synthetic method for intermediate m-nitrophenol of sodium aminosalicylate medicine |
| abstract | A synthetic method for an intermediate m-nitrophenol of a sodium aminosalicylate medicine comprises the following steps: adding 230-330ml of water solution into a reactor provided with a stirrer, a thermometer and a dropping funnel, controlling the temperature of the water solution to be below 5 DEG C below 0, adding a certain amount of concentrated sulfuric acid slowly in batches, after adding, cooling to 20-30 DEG C, and adding a certain amount of 3-nitroaniline (2) in batches, after temperature is reduced to 10-15 DEG C, slowly adding a nitrite solution into the solution of the reactor to obtain heavy amine salt (3) for standby; adding 200-300ml of water solution into another reactor, adding a certain volume of concentrated sulfuric acid, heating the solution to 85-90 DEG C, slowing adding a heavy amine salt solution prepared in step (i), then pouring the solution into a water solution of 5 DEG C below 0, keeping the stirring speed at 300-1000rpm, after a solid is separated out, when the temperature is reduced to 20-25 DEG C, washing with a solvent, adding the washed solution into an acid solution for recrystallization to obtain a product m-nitrophenol. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107935858-A |
| priorityDate | 2015-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 49.