http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105457037-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-704 |
| filingDate | 2014-08-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-06-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-06-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105457037-B |
| titleOfInvention | A stem cell tumor targeting system loaded with nano-prodrug and preparation method thereof |
| abstract | The invention belongs to the technical fields of biomedicine and nano-medicine, and relates to a stem cell tumor targeting system containing nano-prodrugs and a preparation method thereof. The present invention uses stem cells as cell carriers, and prepares an anti-tumor targeting system by endocytosis and loading of nanometer prodrugs. The general formula is: Stem cells—(RGD-PPCD) n . Among them, nano-prodrugs have the characteristics of targeting, sustained release and acid-sensitive release, and stem cell carriers can remotely target tumor primary foci and metastases. The results of in vitro experiments show that the drug-loaded stem cells can maintain their ability to divide and proliferate and the characteristics of tumor migration. Slow release; in vivo experimental results show that compared with the original drug and nano-prodrug, the constructed stem cell targeting system can significantly prolong the survival period of tumor-bearing animals, maintain the normal neurobehavioral characteristics of tumor-bearing animals, and exert its high efficiency , safe and durable anti-tumor efficacy. |
| priorityDate | 2014-08-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 35.