| abstract |
The present disclosure generally relates to compositions comprising a crosslinked cation-binding polymer comprising a carboxylic acid group and a pKa reducing group, including, for example, electron-withdrawing substituents such as halogen atoms (e.g., fluorine), and a base. Monomer, wherein said polymer optionally comprises less than about 20,000 ppm of non-hydrogen cations, and wherein said base is present in an amount sufficient to provide from about 0.2 equivalents to about 0.95 equivalents per equivalent of carboxylic acid groups in said polymer The amount of base present. The present disclosure also relates to methods of making such compositions and methods of using such compositions to treat various diseases or conditions. |