| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7792d2ce107c4fa75edf6482330e84e9 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-17
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-70 |
| filingDate |
2015-12-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a8436d5c47d7eaf4b95a245ab8a7374e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8798ae0d2679516f1d150bee8b4c922d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9d1a789bff2a08d2cb757692a6c080eb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e952e47c9431fc2142eb57bd35b9a3c0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_17ad846679bee6090f3cbe41f0bd4d7e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ef91fac1f4eb06b03f27fd29e9146be9 |
| publicationDate |
2016-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-105441453-A |
| titleOfInvention |
Preparation method for polyethylene glycol-modifiedTRAIL recombinant protein |
| abstract |
The invention belongs to the biotechnology field, and particularly relates to a preparation method for a polyethylene glycol-modified TRAIL recombinant protein. A tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is adopted as an inducing ligand. A chemical modification method is adopted as the preparation method. The preparation method comprises the following steps of 1 HZ-TRAIL preparation; 2 HZ-TRAIL extraction and purification; 3 PEG-HZ-TRAIL preparation; 4 PEG-HZ-TRAIL purification. According to the preparation method for the polyethylene glycol-modified TRAIL recombinant protein, through the method that a TRAIL recombinant gene is improved into a novel PEG-HZ-TRAIL recombinant protein through a PEGylation technique, so that the trimerical high-activity TRAIL protein is prepared; in addition, the advantage of achieving the high pharmacological efficacy on resisting tumors and rheumatoid arthritis is achieved by modifying the tumor necrosis factor-related apoptosis-inducing ligand through polyethylene glycol. |
| priorityDate |
2015-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |