http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105440126-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-635 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-29 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-635 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-04 |
| filingDate | 2015-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105440126-B |
| titleOfInvention | The alpha-helix polypeptide and the preparation method and application thereof for treating osteoporosis |
| abstract | The invention discloses a kind of PTH (1-34) peptide derivants.The invention also discloses the preparation method and application of above-mentioned PTH (1-34) peptide derivant, proposing a kind of PTH (1-34) derivative is that the amino acid on the position of corresponding PTH (1-34) sequence i-th and i+4 or i and i+7 is replaced with Cys, then the compound by being formed after linking arm (linker) cyclization, wherein when position is i and i+4, the value of i is 15,17,18,20,22,25,26,27,29.When position is i and i+7, the value of i is 19,22,25,26.PTH (1-34) derivative prepared by the present invention has the internal efficacy time for being longer than PTH (1-34), particularly suitable for the active constituent in the drug of preparation osteoporosis as the drug. |
| priorityDate | 2015-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 109.