http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105439934-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_feb0b283a46ba26844984ca04b7bb965 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-16 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-16 |
| filingDate | 2015-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a6d36ea7796d51fefa30b3f4d0902452 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_38fc18bb0beefc86959f8d007cb23567 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c2fa03fed89d96f7ca3b3742dcab204f |
| publicationDate | 2016-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105439934-A |
| titleOfInvention | Novel preparation method of ertapenem side chain |
| abstract | The invention relates to an innovation-type preparation method of an ertapenem side chain (represented by the formula 1). The method comprises the steps: (1) with amino protected thiolactone (represented by the formula I) as a raw material, under an acidic condition, with SiO2 and gamma-Al2O3 as carriers, and with a catalyst prepared with palladium as an active ingredient, carrying out a hydrogenation deprotection reaction, to obtain deprotected thiolactone (represented by the formula 2); and (2) carrying out a reaction of the compound 2 and m-aminobenzoic acid, to obtain the target compound (represented by the formula 1). With easily-available, relatively-inexpensive and amino protected thiolactone having a mature preparation process as the raw material, the improved palladium catalyst is innovatively used for hydrogenation deprotection, the compound 2 is obtained, and then the compound 2 is subjected to a reaction with m-aminobenzoic acid to prepare the target compound; the preparation method has the advantages of cheap and easily available raw materials, high product yield, low production cost, economy, safety and environmental protection, and is more suitable for industrialized production. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109574899-A |
| priorityDate | 2015-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 67.