http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105439900-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_122bbcbc574a179c8e4e5eb17c0dae56 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C253-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C253-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C255-35 |
| filingDate | 2015-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8945730e366d5f6b5a4db4547d4e2572 |
| publicationDate | 2016-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105439900-A |
| titleOfInvention | Synthesis method of pyrimethamine drug intermediate p-chlorobenzonitrile |
| abstract | The invention relates to a synthesis method of a pyrimethamine drug intermediate p-chlorobenzonitrile, which comprises the following steps: adding 1.3 mol of p-benzyl chloride and 0.56 mol of stannous chloride into a reaction vessel which is provided with a stirrer, a thermometer, a reflux condenser and a dropping funnel, controlling the stirring rate at 130-160 rpm, heating the solution to 90-95 DEG C, slowly and dropwisely adding 1.5-1.7 mol of cyanamide within 1-2 hours, continuing stirring to react for 4-5 hours, cooling the solution to 10-15 DEG C, adding 230ml of sodium chloride solution, separating out the water layer, washing the oil layer with a salt solution, washing with acetonitrile, carrying out reduced pressure distillation, and recrystallizing the fraction in ethyl acetate to obtain the crystal p-chlorobenzonitrile, wherein the mass percent of the sodium chloride solution is 15-20%, and the salt solution is any one of potassium bromide and sodium nitrate. |
| priorityDate | 2015-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 44.