http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105418737-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-64 |
| filingDate | 2014-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105418737-B |
| titleOfInvention | Solid-phase synthesis method and application of bregma cyclopeptide A |
| abstract | The invention provides a solid-phase synthesis method of bregma cyclopeptide A, which comprises the following steps: 1) synthesis of linear octapeptides: (1-1) providing Fmoc-AA 1 -resin, Fmoc protecting group removal with a deprotecting agent; (1-2) reacting Fmoc-AA in the presence of an activating agent n Respectively carrying out acyl chlorination on-OH monomer amino acids to obtain Fmoc-AA n -Cl monomer amino acid chloride; (1-3) under alkaline conditions, each Fmoc-AA was separately reacted n Sequentially condensing amino acid acyl chloride of a Cl monomer and amino acid on the resin to obtain straight-chain octapeptide resin; (1-4) separating the polypeptide from the resin on the linear octapeptide resin in the presence of a cleavage agent to obtain the linear octapeptide; 2) and cyclizing the obtained straight-chain octapeptide by using a condensation reagent to obtain the short petal cyclopeptide A. The invention provides an application of a solid-phase synthesis method of bregma cyclopeptide A. |
| priorityDate | 2014-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 115.