http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105418706-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H17-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H17-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H17-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-706 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7048 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 |
| filingDate | 2015-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105418706-B |
| titleOfInvention | A kind of macrolides antimicrobial compound and the preparation method and application thereof |
| abstract | The invention belongs to pharmaceutical chemistry technical field, a kind of macrolides antimicrobial compound and the preparation method and application thereof is disclosed.The structure of the macrolides antimicrobial compound is shown in formula I, wherein n is equal to 1 or 2；X is carbon or nitrogen-atoms；R selected from H, C1~6 alkyl, nitro, the alkoxy of C1~6, halogenic substituent and the halogenated alkyl of C1~6 in any one.Its synthetic route is first to react Flurithromycin in hydrochloride buffer, and reaction product is successively reacted with benzoyl oxide, triphosgene and R substituted aryl acid or heterocyclic aryl acid again, and finally the back flow reaction in alcoholic solvent, obtains macrolides antimicrobial compound.Preparation method synthetic route of the invention is simple, and synthetic yield is high；Products therefrom anti-microbial property is good, high to the inhibitory activity of macrolide drug-fast bacteria, has a good application prospect. |
| priorityDate | 2015-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 146.