http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105418589-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 |
| filingDate | 2016-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-09-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-09-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105418589-B |
| titleOfInvention | A kind of esomeprazole magnesium trihydrate preparation method for treating disease of digestive system |
| abstract | The invention discloses a kind of esomeprazole magnesium trihydrate preparation method for treating disease of digestive system, including：1) in the presence of alkali compounds, the methoxy-pyridine hydrochloride of 23,5 dimethyl of chloromethyl 4 and the methoxybenzimidazol of 2 sulfydryl 5 is subjected to back flow reaction in THF and obtain Omeprazole thioether；2) Omeprazole thioether is mixed in acetone with the compound shown in formula A, inorganic metal salt, obtains mixture B；3) temperature is 10 50 DEG C, oxidant is added oxidation reaction is carried out in mixture B, and reaction adds potassium hydroxide methanol solution after terminating, obtains esomeprazole potassium；4) esomeprazole potassium is mixed in methyl alcohol with anhydrous magnesium chloride, stirring reaction, be then centrifuged for, isolated esomeprazole magnesium trihydrate；The inorganic metal salt is cobalt (II), iron (II) or manganese (II) metal salt.High income of the present invention, selectivity are good and reaction efficiency height is adapted to industrial-scale production. |
| priorityDate | 2016-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 97.