http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105418528-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D261-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D261-08 |
| filingDate | 2015-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105418528-B |
| titleOfInvention | A kind of preparation method of Parecoxib Sodium |
| abstract | The invention belongs to field of medicine and chemical technology, more particularly to a kind of preparation method of Parecoxib Sodium, by benzaldoxime (chemical compounds I) and 1 phenyl, 1 propine (compound ii), in the presence of catalyst and acid binding agent, addition reaction occurs and builds isozole ring, obtains Parecoxib Sodium intermediate (compound III)；Sulfonation occurs for compound III, sulfonylation obtains compounds Ⅳ, and compounds Ⅳ obtains Parecoxib Sodium (compound V) with after propionic acid anhydride reactant at salt.The present invention innovatively uses Dipolar Cycloaddition prepare compound III; low toxicity safe to use, the metastable common agents chlorosulfonic acid of property and ammonium hydroxide carry out sulfonylation, have reaction condition is mild, operation rationally, high selectivity, high quality；Supplementary material used is cheap in reaction, reduces production cost. |
| priorityDate | 2015-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 90.