http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105418506-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D235-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D235-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D285-135 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-454 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-75 |
| filingDate | 2014-09-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105418506-B |
| titleOfInvention | Acetylbenzylamine piperazine derivatives and their application as neuroprotective agents |
| abstract | The present invention discloses a acetylbenzylamine piperazine derivative and its application as a brain neuroprotectant. Pharmacological experiments show that the compound of the present invention not only exhibits obvious anti-glutamate-induced neuron excitotoxicity in vitro , there is significant hypoxia resistance activity in mice, and the herg test also shows that the compound of the present invention has no risk of cardiotoxicity. Therefore, the compound of the present invention has the advantages of high activity, few side effects, and good druggability. The compound and its pharmaceutical preparations have good curative effect on treating cranial nerve injury diseases, such as cerebral apoplexy and related diseases, and do not have cardiac Toxicity risk. The acetylbenzylamine piperazine derivatives are free bases or salts of compounds with the following general chemical structure: . |
| priorityDate | 2014-09-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 162.