http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105412939-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2014-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105412939-B |
| titleOfInvention | A kind of adriamycin co-supported medicine system, preparation method and application |
| abstract | The invention discloses a kind of adriamycin co-supported medicine system, preparation method and applications.The adriamycin co-supported medicine system, including adriamycin active constituent and targeting vector；Its surface of the targeting vector is covalently bonded with targeting ligand, and carries siRNA, for inhibiting oncogene expression；The adriamycin active constituent accounts for the drug-loading system mass percent altogether between 4% to 8%；The targeting ligand accounts for the drug-loading system mass percent altogether between 1% to 10%；The small interference accounts for the drug-loading system mass percent altogether between 0.5% to 2%.Preparation method includes the following steps：(1) targeting conjugate of folate ligand is prepared；(2) adriamycin co-supported medicine system precursors are prepared；(3) adriamycin co-supported medicine system is prepared.Adriamycin co-supported medicine system provided by the invention, targeting is good, active anticancer is strong, toxicity is low, it is not easy to generate drug resistance, be particularly suitable for preparing targeting solid tumor resisting medicine. |
| priorityDate | 2014-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 96.