http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105399755-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D505-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D505-06 |
| filingDate | 2015-11-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105399755-B |
| titleOfInvention | A kind of synthetic method of Flomoxef acid |
| abstract | The present invention relates to a kind of synthetic method of Flomoxef acid, method are as follows：1) by compound (I) in organic solvent, under organic base catalytic and di-tert-butyl dicarbonate generates compound (II), 2) in organic solvent and N, compound (III) is generated under the action of N ' diethyl ethylenediamines, 3) compound (IV) is generated by methoxylation, 4) compound (IV) is attached to obtain compound (V) with tetrazole side chain, 5) slough amino under trifluoroacetic acid effect and carboxyl-protecting group obtains compound (VI), 6) it is sour (VII) by obtaining Flomoxef with the intermediate reaction of difluoromethyl thioacetic acid active ester.Reaction scheme is as follows： Method high income provided by the invention, reaction condition are gentle, post processing is simple and convenient, tetrazole side chain need not protection, the problem of avoiding the use of the higher boiling reagent such as the hazardous agents such as phosphorus pentachloride and methyl phenyl ethers anisole and metal residual in deprotection reaction. |
| priorityDate | 2015-11-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 110.