http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105399680-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C233-47 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 |
| filingDate | 2015-09-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105399680-B |
| titleOfInvention | Chiral more PCBN tools and preparation method and application |
| abstract | The invention discloses a kind of chiral more PCBN tools and preparation method and application, belong to protein inhibitor technical field.Solve in the prior art, POMs lacks targeting, and recognition capability is poor under the biotic environment system of complexity, can not realize the technical problem of clinical practice.Chiral more PCBN tools of the present invention, shown in structural formula such as formula (I), in formula, R is L His, D His, L Asp, D Asp, L Leu, D Leu, L Phe or D Phe take off the residue of an amino hydrogen.The more PCBN tools of the chirality can be used as A beta inhibitor applications, can penetrate blood-brain barrier, realize under physiological environment, have high affinity and selectivity to A β, and the means of more horn of plenty are provided for AD treatment. |
| priorityDate | 2015-09-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 53.