http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105384809-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-635 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-635 |
| filingDate | 2015-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105384809-B |
| titleOfInvention | A kind of method that segment method solid-liquid combination prepares Teriparatide |
| abstract | The invention belongs to Peptides Synthesis, it is related to a kind of method that solid-liquid combination prepares Teriparatide, the present invention uses liquid phase mode composite part dipeptides and tripeptide fragment, it is fed intake again with synthesized dipeptides and tripeptide fragment, reduce 13 step solid phase reactions, coupling efficiency greatly improved, not only avoids the generation for 34 end racemization impurity for being difficult to purify removing, and the generation of multiple site deletion peptides is also avoided, final goal peptide purity reaches 75% or more.Compared with prior art, synthetic route of the present invention is simple, and solid phase coupling step number is few, has focused on solving the too long coupling difficulty of peptide sequence, has been easy to produce the problem of peptide disappearance, and segment synthetic technology is mature, Material Cost reduces, and is able to carry out industrial mass production. |
| priorityDate | 2015-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 125.