abstract |
The present invention relates to derivatives of GLP-1-like peptides, which are C-terminally extended analogs of native GLP-1. The derivative comprises two side chains, one at a position corresponding to position 42, and one at a position corresponding to position 18, 23, 27, 31, 36 or 38, two of which are associated with GLP-1. (7‑37) for comparison. The side chain comprises a C19, C20 or C22 diacid extension and an optional linker. The present invention also relates to intermediates in the form of novel GLP-1 analogs incorporated into the derivatives of the present invention, as well as pharmaceutical compositions and medical uses of said derivatives. The derivatives have extremely long half-lives while maintaining satisfactory potency, which makes them potentially suitable for once-monthly administration. |